Research

Publications

Sule, P., Tilvawala, R., Mustapha, T., Hassounah, H., Noormohamed, A., Kundu, S., Graviss, E. A., Walkup, G. K., Kong, Y., & Cirillo, J. D. (2019). Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence. Journal of clinical microbiology57(12), e01462-19. https://doi.org/10.1128/JCM.01462-19

M.S. Durkee, J.D. Cirillo, K.C. Maitland (2019). Fluorescent modeling of in vivo optical detection of Mycobacterium tuberculosisBiomed. Opt. Express 10:5445-5460.

H.J. Yang, Y. Kong, Y. Cheng, H. Janagama, H. Hassounah, H. Xie, J. Rao, J.D. Cirillo (2017).  Real-time imaging of Mycobacterium tuberculosis using a novel near-infrared fluorescent substrate.  J. Infect. Dis. 215:405-414. PMCID: PMC6061879

F. Nooshabadi, H.J. Yang, Y. Cheng, M.S. Durkee, H. Xie, J. Rao, J.D. Cirillo, K.C. Maitland (2017).  Intravital excitation increases detection sensitivity for pulmonary tuberculosis by whole-body imaging with b-lactamase reporter enzyme fluorescence. J. Biophotonics. 10:821-829. PMCID: PMC5703064.

Sule, P., Tilvawala, R., Behinaein, P., Walkup, G. K., & Cirillo, J. D. (2016). New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform. Tuberculosis (Edinburgh, Scotland)101S, S78–S82. https://doi.org/10.1016/j.tube.2016.09.009

Cheng, Y., Xie, H., Sule, P., Hassounah, H., Graviss, E. A., Kong, Y., Cirillo, J. D., & Rao, J. (2014). 
Fluorogenic probes with substitutions at the 2 and 7 positions of cephalosporin are highly BlaC-specific for 
rapid Mycobacterium tuberculosis detection. Angewandte Chemie (International ed. in English), 53(35), 
9360–9364. https://doi.org/10.1002/anie.201405243 
Xie, H., Mire, J., Kong, Y., Chang, M., Hassounah, H. A., Thornton, C. N., Sacchettini, J. C., Cirillo, J. D., & Rao, J. (2012). Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic 
probe. Nature chemistry, 4(10), 802–809. https://doi.org/10.1038/nchem.1435 
Kong, Y., Yao, H., Ren, H., Subbian, S., Cirillo, S. L., Sacchettini, J. C., Rao, J., & Cirillo, J. D. (2010). 
Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice. 
Proceedings of the National Academy of Sciences of the United States of America, 107(27), 12239–12244. 
https://doi.org/10.1073/pnas.1000643107